October 2006:
OptiGen, LLC (Ithica, NY) determined through DNA testing of the first
two reported PRA-affected Spanish Water Dogs worldwide (Finland and USA)
were both positive for prcd-PRA.
The prcd form of PRA causes the
retina at the back of the eye to degenerate as the dog matures. The "rod"
cells (which operate in low light) are the first to degenerate, leading to
night blindness. Eventually, the "cone" (high light) cells also become
affected, causing full blindness. The disease is inherited through a simple
recessive allele.
prcd-PRA is found in many
breeds, and the average age of onset differs with each breed. In the USA
dog, the disease was first positively diagnosed at 4.5 years of age through
a routine CERF examination; the dog is still outwardly subclinical. The
Finnish dog was diagosed at 8 years of age when he began refusing to run
through dark tunnels at agility training.
OptiGen now offers
DNA testing to determine the genetic status of individual dogs: Clear,
Carrier, or Affected. With this knowledge, breeders will be able to first
control, and eventually breed out the incidence of the prcd-PRA in
our breed.
The SWD Club Health and
Wellness committee greatly thanks OptiGen and the owners of the first two
diagnosed dogs for their participation and good will in this important
discovery.
For more information on prcd-PRA
or OptiGen, visit the OptiGen website at:
http://www.optigen.com.
For more information on Occular
Disorders in Spanish Water Dogs, click here.