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Exocrine Issues in Spanish Water DogsExocrine Pancreatic InsufficiencyEPI is a disorder which occurs in many canine breeds, in particular the German Shepherd Dog. The first and only publicly announced case of this disorder in the Spanish Water Dog breed occurred in December, 2006. The Disease The pancreas has two major functions:
Exocrine pancreatic insufficiency (EPI) is the inability of the pancreas to secrete the necessary digestive enzymes, amylase to digest starches, lipases to digest fats, and trypsin and proteases to digest protein. When these enzymes are not available to help digest nutrients, the nutrients cannot be used by the body. The body in essence starts to starve. In addition, due to the lack of proper digestion of nutrients, exocrine pancreatic insufficiency is usually accompanied by structural and functional changes in the tissue lining of the small intestine that further impairs nutrient absorption called small intestinal bacterial overgrowth (SIBO). Untreated or misdiagnosed dogs with EPI will either die a painful death by starvation or organ failure.
Symptoms
These symptoms are not exhibited until 85% -90% of the pancreas is destroyed. Testing A trypsin-like immunoreativity (cTLI) blood test (Texas A & M University labs are most widely used) will show the dog's ability to produce digestive enzymes (lipase, protease, amylase). The normal range is between 5.0 – 35.0. The dog must fast 12 hours prior to blood test. cTLI tests range approximately $100. Treatment Treatment of exocrine pancreatic insufficiency may be regulated after some trial and error with enzyme replacement. It is usually necessary for life. Most dogs with EPI respond well to pancreatic enzyme replacement with every meal, antibiotics to reduce the SIBO (small intestinal bacterial overgrowth) condition and a change in diet to a low fat, low-fiber diet. Raw diets are also being met with success. All grains need to be avoided. Sadly, not every vet recognizes the symptoms, misdiagnose these dogs who then eventually die a painful death - - or are put down because the enzyme treatment is so expensive. Where does EPI come from??? EPI is suspected to be caused by autosomal recessive genes, but it is unclear if it is by one gene or multiple loci, possibly a polygenic inheritance (traits vary in degrees of severity of the disease). In a simple recessive scenario, an affected animal must inherit 2 copies of the gene, 1 from each parent. Dogs with the genotype PP (normal) or Pp (carrier) will be clinically normal but the carrier will pass the affected gene to approximately half the offspring. As long as carriers (Pp) are mated to normal animals (PP), the offspring will be unaffected but some will remain carriers. If 2 carriers are mated, some of the offspring (approximately 25%) will be affected. BUT even then, one may not know that the dog has the disease. Symptoms may be exacerbated by physical or emotional stress. What we can do! We now know this condition exists in the SWD lines, however at this point we can only test to confirm if a dog is affected by EPI. An effort spear-headed by SWD Club member Olesia Kennedy brings together the EPI Global Group and Texas A&M Medical University to identify genetic markers for this insidious disease. If you dog has EPI, or you suspect your dog has EPI, please feel free to e-mail Olesia Kennedy for assistance with enzymes, contacts, testing, or general questions; or visit http://EPI-Research-Fund.com . The Researchers
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And with special collaboration of:
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Copyright © 2005
Spanish Water Dog Club
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